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Dimethyl sulfoxide (DMSO) is a sulfur-containing organic compound. Due to its structure comprising one hydrophilic sulfinyl group and two hydrophobic methyl groups, it is miscible with aqueous solutions as well as most organic solvents except petroleum ether. Capable of dissolving approximately 80% of compounds, it has earned the title of "universal solvent".
Common Experimental Applications:
1. Cell Cryopreservation
DMSO is an effective cryoprotectant that reduces ice crystal formation during cell cryopreservation, minimizing physical damage to cells caused by ice crystals. Additionally, DMSO enhances cell membrane permeability, enabling cells to more easily absorb cryoprotectants—thereby improving cell survival rates under low-temperature conditions.
2. Solvent for Drugs and Compounds
With excellent solvency power, DMSO can dissolve organic compounds (including various drugs) that are difficult to dissolve in many other solvents. This makes it an ideal solvent for drug screening and cell therapy research.
3. Penetration Enhancer
The permeation property of DMSO allows it to increase cell membrane permeability, facilitating the entry of molecules such as drugs and DNA into cells.
4. Applications in Chemical and Biological Reactions
In certain chemical synthesis processes and enzymatic reactions, DMSO can serve as a reaction medium to promote reaction progression or improve reaction efficiency. It may also affect cellular signal transduction pathways—a side effect that can be useful for studying cell biological processes in some cases.
PanReac AppliChem’s pharmacopoeia-grade dimethyl sulfoxide (Catalog No.: 191954) is manufactured in Europe. Featuring high purity, ultra-low metal ion content, and compliance with the ICH Q3D quality standard, it meets the requirements of multiple pharmacopoeias including USP (United States Pharmacopeia), Ph Eur (European Pharmacopoeia), and BP (British Pharmacopoeia). With superior quality at a competitive price and stable supply, it is available in various specifications (1L, 2.5L, 5L, 25L, 190L) to meet the needs of different applications and process stages. It has long been widely favored by customers worldwide.
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